August 17, 2021, 17:00-20:00 CEST/UTC+2
Timeslot | Titel of session and information |
---|---|
17:00-17:15 | Welcome by organizers and JIM editor-in-chief |
17:15-18:00 | Session 1. Molecular and cellular make-up of the BBB and its regulation |
Q&A and thematic discussion. Discussion leaders: Matthew Campbell and Christer Betsholtz | |
Panel: | |
Benoit Vanhollebeke, Université Libre de Bruxelles, Belgium | |
Single-cell control mechanism of brain angiogenesis and blood-brain barrier formation in vertebrates | |
Peter Carlsson, University of Gothenburg, Sweden | |
Foxf2 control of brain endothelial metabolism and consequences for neuronal health and survival | |
Matthew Campbell, Trinity College Dublin, Ireland | |
Dynamic regulation of claudin-5 at the blood-brain and blood-retina barrier | |
Christer Betsholtz, Karolinska Institutet and Uppsala University, Sweden | |
Mapping brain barriers by single-cell RNA sequencing | |
18:00-18:10 | Break |
18:10-19:05 | Session 2. Pharmacological targeting of the CNS |
Q&A and thematic discussion. Discussion leaders: Stina Syvänen and Margareta Hammarlund-Udenaes | |
Panel: | |
Prakash Ambady and Edward Neuwelt, Oregon Health & Science University, USA | |
Looking back at the past 50 years of intra-arterial delivery and blood-brain barrier disruption. | |
Margareta Hammarlund-Udenaes, Uppsala University, Sweden | |
Targeting CNS disorders – is enough drug reaching the brain? On drug delivery across the blood-brain barrier. | |
Joy Zuchero, Denali Therapeutic Inc. USA | |
Using the Transport Vehicle to Deliver CNS Therapeutics Across the Blood-Brain Barrier | |
Stina Syvänen, Uppsala University, Sweden | |
Bispecific brain penetrating antibodies for PET imaging and therapy | |
Viviana Gradinaru, Caltech, USA | |
Engineered gene delivery vectors for high-precision minimally-invasive access to and across the brain vasculature across species | |
19:05-19:15 | Break |
19:15-20:00 | Session 3. Barrier facets and heterogeneity inside and immediately outside of the CNS |
Q&A and thematic discussion. Discussion leaders: Stefan Liebner and Maria Lehtinen | |
Panel: | |
Maiken Nedergaard, Nedergaard Lab, USA and University of Copenhagen, Denmark | |
The Glymphatic System | |
Maria Lehtinen, Boston Children’s Hospital, USA | |
New roles for the blood-CSF barrier in health and disease | |
Kari Alitalo, University of Helsinki, Finland | |
Targeting meningeal lymphatics in CNS disease | |
Stefan Liebner, Goethe University Frankfurt, Germany | |
Regulation of endothelial permeability in circumventricular organs (CVOs) – sites of neurovascular coupling |
August 18, 2021, 17:00-20:00 CEST/UTC+2
Timeslot | Titel of session and information |
---|---|
17:00-17:45 | Session 4. The BBB in brain tumors |
Q&A and thematic discussion. Discussion leaders: Timothy Phoenix and William Elmquist | |
Panel: | |
Jann Sarkaria, Mayo Clinic, USA | |
Distribution of the novel DNA-PK inhibitor nedisertib into brain and brain tumor and the impact on radiation sensitivity | |
Timothy Phoenix, University of Cincinnati, USA | |
Drivers of vascular heterogeneity in brain tumors | |
William Elmquist, University of Minnesota, USA | |
Heterogeneity in Transport Mechanisms at the BBB: A critical determinant of efficacy in brain tumors | |
Christer Betsholtz, Karolinska Institutet and Uppsala University, Sweden | |
Mapping brain barriers by single-cell RNA sequencing | |
17:45-18:00 | Break |
18:00-18:45 | Session 5. Immune mechanisms in CNS health and disease |
Q&A and thematic discussion. Discussion leaders: Britta Engelhardt and Rudolph Tanzi | |
Panel: | |
Britta Engelhardt, University of Bern, Switzerland | |
The brain barriers maintain CNS immune privilege | |
Annika Keller, University Hospital Zurich, Switzerland | |
Pericytes regulate vascular immune homeostasis in the CNS | |
Katerina Akassoglou, University of California, USA | |
The immunology of blood: Unlocking drivers of neurodegeneration | |
Rudolph Tanzi, Massachusetts General Hospital East, USA | |
The Role of Innate Immunity in Alzheimer’s Disease Pathogenesis | |
18:45-19:00 | Break |
19:00-19:45 | Session 6. The BBB in Alzheimer’s and other neurodegenerative diseases |
Q&A and thematic discussion. Discussion leaders. Berislav Zlokovic and Li-Huei Tsai | |
Panel: | |
Li-Huei Tsai, Massachusetts Institute of Technology, USA | |
Using human stem cells and postmortem brains to study vascular dysfunction in Alzheimer’s disease | |
Berislav V. Zlokovic, University of Southern California, USA | |
Blood-brain barrier Link to Neurodegeneration: Implications for cognitive impairment, dementia and Alzheimer’s disease | |
Katerina Akassoglou, University of California, USA | |
The immunology of blood: Unlocking drivers of neurodegeneration | |
Rudolph Tanzi, Massachusetts General Hospital East, USA | |
The Role of Innate Immunity in Alzheimer’s Disease Pathogenesis | |
19:45-20:00 | Concluding remarks. Meeting ends |
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