August 17, 2021, 17:00-20:00 CEST/UTC+2

TimeslotTitel of session and information
17:00-17:15Welcome by organizers and JIM editor-in-chief
17:15-18:00Session 1. Molecular and cellular make-up of the BBB and its regulation
Q&A and thematic discussion. Discussion leaders: Matthew Campbell and Christer Betsholtz
Panel:
Benoit Vanhollebeke, Université Libre de Bruxelles, Belgium
Single-cell control mechanism of brain angiogenesis and blood-brain barrier formation in vertebrates
Peter Carlsson, University of Gothenburg, Sweden
Foxf2 control of brain endothelial metabolism and consequences for neuronal health and survival
Matthew Campbell, Trinity College Dublin, Ireland
Dynamic regulation of claudin-5 at the blood-brain and blood-retina barrier
Christer Betsholtz, Karolinska Institutet and Uppsala University, Sweden
Mapping brain barriers by single-cell RNA sequencing
18:00-18:10Break
18:10-19:05Session 2. Pharmacological targeting of the CNS
Q&A and thematic discussion. Discussion leaders: Stina Syvänen and Margareta Hammarlund-Udenaes
Panel:
Prakash Ambady and Edward Neuwelt, Oregon Health & Science University, USA
Looking back at the past 50 years of intra-arterial delivery and blood-brain barrier disruption.
Margareta Hammarlund-Udenaes, Uppsala University, Sweden
Targeting CNS disorders – is enough drug reaching the brain? On drug delivery across the blood-brain barrier.
Joy Zuchero, Denali Therapeutic Inc. USA
Using the Transport Vehicle to Deliver CNS Therapeutics Across the Blood-Brain Barrier
Stina Syvänen, Uppsala University, Sweden
Bispecific brain penetrating antibodies for PET imaging and therapy
Viviana Gradinaru, Caltech, USA
Engineered gene delivery vectors for high-precision minimally-invasive access to and across the brain vasculature across species
19:05-19:15Break
19:15-20:00Session 3. Barrier facets and heterogeneity inside and immediately outside of the CNS
Q&A and thematic discussion. Discussion leaders: Stefan Liebner and Maria Lehtinen
Panel:
Maiken Nedergaard, Nedergaard Lab, USA and University of Copenhagen, Denmark
The Glymphatic System
Maria Lehtinen, Boston Children’s Hospital, USA
New roles for the blood-CSF barrier in health and disease
Kari Alitalo, University of Helsinki, Finland
Targeting meningeal lymphatics in CNS disease
Stefan Liebner, Goethe University Frankfurt, Germany
Regulation of endothelial permeability in circumventricular organs (CVOs) – sites of neurovascular coupling

August 18, 2021, 17:00-20:00 CEST/UTC+2

TimeslotTitel of session and information
17:00-17:45Session 4. The BBB in brain tumors
Q&A and thematic discussion. Discussion leaders: Timothy Phoenix and William Elmquist
Panel:
Jann Sarkaria, Mayo Clinic, USA
Distribution of the novel DNA-PK inhibitor nedisertib into brain and brain tumor and the impact on radiation sensitivity
Timothy Phoenix, University of Cincinnati, USA
Drivers of vascular heterogeneity in brain tumors
William Elmquist, University of Minnesota, USA
Heterogeneity in Transport Mechanisms at the BBB: A critical determinant of efficacy in brain tumors
Christer Betsholtz, Karolinska Institutet and Uppsala University, Sweden
Mapping brain barriers by single-cell RNA sequencing
17:45-18:00Break
18:00-18:45Session 5. Immune mechanisms in CNS health and disease
Q&A and thematic discussion. Discussion leaders: Britta Engelhardt and Rudolph Tanzi
Panel:
Britta Engelhardt, University of Bern, Switzerland
The brain barriers maintain CNS immune privilege
Annika Keller, University Hospital Zurich, Switzerland
Pericytes regulate vascular immune homeostasis in the CNS
Katerina Akassoglou, University of California, USA
The immunology of blood: Unlocking drivers of neurodegeneration
Rudolph Tanzi, Massachusetts General Hospital East, USA
The Role of Innate Immunity in Alzheimer’s Disease Pathogenesis
18:45-19:00Break
19:00-19:45Session 6. The BBB in Alzheimer’s and other neurodegenerative diseases
Q&A and thematic discussion. Discussion leaders. Berislav Zlokovic and Li-Huei Tsai
Panel:
Li-Huei Tsai, Massachusetts Institute of Technology, USA
Using human stem cells and postmortem brains to study vascular dysfunction in Alzheimer’s disease
Berislav V. Zlokovic, University of Southern California, USA
Blood-brain barrier Link to Neurodegeneration: Implications for cognitive impairment, dementia and Alzheimer’s disease
Katerina Akassoglou, University of California, USA
The immunology of blood: Unlocking drivers of neurodegeneration
Rudolph Tanzi, Massachusetts General Hospital East, USA
The Role of Innate Immunity in Alzheimer’s Disease Pathogenesis
19:45-20:00Concluding remarks. Meeting ends

Hosted by

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Uppsala University. Logotype.
Karolinska Institutet. Logotype.
Keck school of medicine of USC. Logotype.
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Professional Conference Organiser

For general information, please contact:

bloodbrainbarrier2021@akademikonferens.se

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